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ECOPOL™ L 30D-55
Description:
ECOPOL™ L 30D-55 is a ready-to-use enteric coating system reconstituted using purified water as solvent with addition of plasticizer, glidant & colorants.
Recommended Solvent System:
For total batch size of 1.0 Kg., 233.0 g. of ECOPOL™ L 30D-55 is required with 338.068 g. of water as total solids content is 18.0 %.
Equipment:
- Stainless steel vessel with a capacity that is 25% higher than the total dispersion volume.
- The height of the vessel should be nearly 25% more than its diameter.
- The speed of the propeller stirrer should be variable and its blade diameter should be nearly 1/3rd of the vessel diameter. (As shown in Figure, h > d and ds = (1/3)d)
Reconstitution procedure:
- Take recommended quantity of Titanium dioxide, Talc, Polysorbate 80 & of plasticizer (DEP) into Purified Water under stirring & pass through the colloidal mill/homogenizer for 10 mins & filter the homogenized colloidal solution/dispersion through # 80 meshes.
- Prepare Sodium Hydroxide solution by dissolving recommended quantity of NaOH in Purified Water.
- Add slowly the prepared NaOH solution into ECOPOL™L 30D-55 dispersion with continuous stirring for 30 minutes. Then add the prepared colloidal solution/dispersion into it at continuous stirring & continue the stirring throughout the coating process.
Precautions:
- The use of high speed stirrer or homogenizer is not recommended.
- The prepared dispersion should not be passed through colloid mill.
- The dispersion may need gentle stirring during the operation to prevent settling.
Coating parameters for ECOPOL™L 30D-55
Parameters |
Auto coater |
Conventional Pan |
Pan diameter |
24” |
48” |
60” |
12” |
36” |
Solvent |
Aqueous |
Aqueous |
Aqueous |
Aqueous |
Aqueous |
Solids content (% w/w) |
18 |
18 |
18 |
18 |
18 |
Pan speed* (rpm) |
10-14 |
3-5 |
1.5-3 |
18-20 |
8-12 |
Baffles |
4-6 |
6-8 |
6-10 |
3 |
4 |
Tablet charge**(kg) |
10-15 |
100-130 |
250-300 |
0.5-1 |
40-50 |
Tablet bed temperature (ºC) |
38-40 |
38-40 |
38-40 |
38-40 |
38-40 |
Spray nozzle (mm) |
1 |
1.2-1.5 |
1.2-1.5 |
1 |
1.2 |
Number of spray guns |
1 |
2-3 |
4-6 |
1 |
1 |
Atomizing air pressure (bars) |
1.5-2.5 |
2.0-2.8 |
2.0-3.0 |
1.2-1.8 |
1.5-2.2 |
Spray procedure |
Continuous |
Continuous |
Continuous |
Continuous |
Continuous |
Spray rate (g/min) |
15-20 |
125-175 |
275-325 |
4-6 |
50-60 |
Inlet air temperature (ºC) |
65-70 |
65-70 |
65-70 |
65-70 |
65-70 |
Weight gain (%) |
8 |
8 |
8 |
8 |
8 |
* Pan speed would depend upon the tablet shape, size, friability and the number of baffles, so as to effect proper mixing during the coating process.
** Tablet charge would vary depending upon the tablet shape and size. |
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